When Moshe first saw the Sneh (burning bush), he didn't understand why the bush was not being consumed. When Hashem saw that he was coming closer to look, he told him to take off his shoes because he was standing on holy ground.
My Tanya Rebbi explained this as having to do with a person struggling with his Tayvos. The Yetzer Hara keeps burning, but the bush is not destroyed. When a person is struggling, they might think that their Neshamos are being destroyed. But if they take a closer look, the bush is untainted - it isn't even blackened by smoke. Your Neshama is as clean as it was before the fire started, it is all an allusion that the Y"H has concocted for you, so that you should give up and be his best friend for life.
Take off your shoes - dump the Y"H, because your struggle is nothing less than holy ground. The holiest of the holy. Use your past falls to propel yourself to greater heights. Know that while you were struggling, every time you said "no", the Shechina soared on high and was receiving tremendous bounty from the OHR AIN SOF.
Now when you dust yourself off and start the climb again, be assured that you will shlep many others out of the mud with you.